The 1910 William & Mary Orange and Black football team represented the College of William & Mary as a member of the Eastern Virginia Intercollegiate Athletic Association (EVIAA) during the 1910 college football season. Led by third-year head coach J. Merrill Blanchard, who returned to William & Mary after helming the team in 1904 and 1905, the Orange and Black finished the season with an overall record of 1–7–1 and mark of 1–2 in EVIAA play.
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